Dr. Cimona Hinton
Department of Biological Sciences
Clark Atlanta University
B.S. University of Maryland Eastern Shore
Ph.D. Meharry Medical College
PostDoctoral: Harvard Medical School and Beth Israel Deaconess Medical Center
Our laboratory focuses on mechanisms responsible for cancer cell metastasis at both the cellular and molecular levels. In this regard, we currently study the involvement of chemokine pathways that induce motility of cancer cells. The primary objective is to study how the CXCR4/CXCL12 signaling axis may aid in the migration and invasion of foreign tissues under cancerous condition. This system is studied in prostate and breast cancer cells.
The following are some of the specific projects in our laboratory:
· The role of tumor suppressors in CXCR4-mediated metastasis.
· The role of cannabinoinds in anti-tumorigenesis and anti-cancinogenesis
Chetram, M.A. and Hinton, C.V. (2012) ROS-mediated regulation of CXCR4 in cancer: Frontiers in Biology: Epub ahead of print
Chetram, M.A., Don-Salu-Hewage A.S., and Hinton, C.V. (2011) ROS Enhances CXCR4-mediated Functions through Inactivation of PTEN in Prostate Cancer Cells: Biochemical and Biophysical Research Communications: 410(2):195-200
Chetram, M.A., Odero-Marah, V. and Hinton, C.V. (2010)Loss of PTEN Permits CXCR4-mediated Tumorigenesis through ERK1/2 in Prostate Cancer Cells: Molecular Cancer Research: Jan;9(1):90-102
Hinton, C.V., and Avraham, H.K. (2010) CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain: Clinical andExperimental Metastasis: 27: 97-105
Avraham, H.K., Hinton, C.V., Seng, S., Jiang, S., Avraham, R., and Avraham, S. (2010) “Mechanism of VEGF mediated survival of breast cancer cells”: Cancer Metastasis. Editor: Pranela Rameshwar. Transworld Research Network: Kerala, 1-12, ISBN: 978-81-7895-317-5
Hinton, C.V., Avraham, S. and Avraham, H.K. (2008) Contributions of integrin-linked kinase in breast cancer metastasis and tumorigenesis: Journal of Cellular and Molecular Medicine: Sep-Oct;12(5A):1517-26
Hinton, C.V., Fitzgerald, L.D., and Thompson, M.E. (2007)Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1: Experimental Cell Research 313: 1735-1744.
Lee, T.H., Seng, S., Sekine, M., Hinton, C., Fu, Y., (2007) Avraham, H.K. and Avraham, S. Vascular
Endothelial Growth Factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR-1/Flt-1: PLOS Medicine 4: 1-16.